Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit
نویسندگان
چکیده
منابع مشابه
Signaling Diversity of PKA Achieved Via a Ca2+-cAMP-PKA Oscillatory Circuit
Many protein kinases are key nodal signaling molecules that regulate a wide range of cellular functions. These functions may require complex spatiotemporal regulation of kinase activities. Here, we show that protein kinase A (PKA), Ca(2+) and cyclic AMP (cAMP) oscillate in sync in insulin-secreting MIN6 beta cells, forming a highly integrated oscillatory circuit. We found that PKA activity was ...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2010
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.478